The efficiency of effervescence has been scientifically proven as a highly effective delivery method of active ingredients to the human system. Often the human digestive system may not be in a optimum condition to permit the essential ingredients of a product to carry out their function. This may be especially so as we age. However, science has now proven that effervescence may improve adsorption and bioavailability of active ingredients thereby resulting in a higher potential and probability of effectiveness. Below is a selection of research papers that offer a commentary on the effectiveness of effervescence by drawing on a number of academic studies that examine the issue.THESE STUDIES ARE ENTIRELY INDEPENDENT. THEY HAVE BEEN CARRIED OUT BY ACCREDITED ACADEMICS AND RELATED INSTITUTIONS AND ARE NOT CONNECTED TO OR CONCERNED WITH EMUNOAIR.
1. Controlled release effervescent buccal discs of buspirone hydrochloride: in vitro and in vivo evaluation studies.
Effervescent and non-effervescent buccal disc of BS using HPMC were successfully prepared using direct compression method. Drug release rate from effervescent buccal discs was directly proportional to amount of effervescence forming agent. In vivo pharmacokinetic studies revealed that effervescent HPMC buccal discs give significantly higher bioavailability when compared to that of non-effervescent buccal discs. Hence, effervescent buccal discs can be used as an alternative to improve the drug permeation resulting in better bioavailability.
2. Effervescent dry powder for respiratory drug delivery
A new formulation was established for the use in the pulmonary route of administration. The new formulation contained effervescent and lubricant excipients. The active release mechanism increased drug dissolution and enhanced the dispersion of nanoparticles over the effervescent gas bubble interface. These carrier particles can be synthesized with an adequate particle size for deep lung deposition. Furthermore, effervescent carrier particles can be used to deliver a large range of substances to the lungs with possibly a faster release compared to conventional carrier particles.
3. Coenzyme Q10: Clinical Update and Bioavailability
The time to reach maximum plasma concentration, however, was significantly shorter for the fast-melting and effervescent formulations compared with the soft gel and powder-filled forms, suggesting that the fast-melting and effervescent formulations provided a more rapid delivery of CoQ10 to the blood while exhibiting a similar area under the curve value compared with current formulations